/* ==========================================================================
   ESA-PSS-M — MDS Foundation · powered by Workfutur
   ========================================================================== */

:root{
  --navy:#0B2A45;
  --navy-700:#123A5C;
  --ink:#12212E;
  --teal:#0E7C86;
  --teal-700:#0A5F68;
  --accent:#12A594;
  --bg:#F2F6F8;
  --card:#FFFFFF;
  --line:#DCE5EA;
  --line-soft:#EAF0F3;
  --muted:#5B7285;
  --ok:#1B7F4B;
  --ok-bg:#E7F4EC;
  --warn:#A86400;
  --warn-bg:#FDF3E2;
  --bad:#B3261E;
  --bad-bg:#FBEAE9;
  --radius:16px;
  --radius-sm:10px;
  --shadow:0 1px 2px rgba(11,42,69,.06), 0 8px 24px rgba(11,42,69,.06);
  --shadow-lg:0 2px 4px rgba(11,42,69,.06), 0 18px 48px rgba(11,42,69,.10);
  --font:"Inter","Segoe UI",system-ui,-apple-system,"Helvetica Neue",Arial,sans-serif;
}

*,*::before,*::after{box-sizing:border-box}
[hidden]{display:none !important}

html{-webkit-text-size-adjust:100%}
body{
  margin:0;
  font-family:var(--font);
  color:var(--ink);
  background:var(--bg);
  font-size:16px;
  line-height:1.5;
  -webkit-font-smoothing:antialiased;
}
a{color:var(--teal-700);text-decoration:none}
a:hover{text-decoration:underline}
h1,h2,h3,h4{margin:0;line-height:1.25;letter-spacing:-.01em}
p{margin:0 0 .75em}
small{font-size:.82rem}

/* ---------- header ---------- */
.site-header{
  position:sticky;top:0;z-index:50;
  background:rgba(255,255,255,.92);
  backdrop-filter:saturate(180%) blur(12px);
  border-bottom:1px solid var(--line);
}
.header-inner{
  max-width:1180px;margin:0 auto;padding:12px 20px;
  display:flex;align-items:center;gap:16px;
}
.brand{display:flex;align-items:center;gap:12px;min-width:0}
.brand-mark{
  width:40px;height:40px;border-radius:11px;flex:0 0 auto;
  background:linear-gradient(145deg,var(--navy),var(--teal));
  display:grid;place-items:center;color:#fff;font-weight:800;font-size:.78rem;letter-spacing:.02em;
}
.brand-text{display:flex;flex-direction:column;min-width:0}
.brand-name{font-weight:800;font-size:1.02rem;color:var(--navy);letter-spacing:-.02em;white-space:nowrap}
.brand-sub{font-size:.72rem;color:var(--muted);white-space:nowrap;overflow:hidden;text-overflow:ellipsis}
.header-spacer{flex:1}
.lang-switch{display:flex;border:1px solid var(--line);border-radius:999px;overflow:hidden;background:#fff}
.lang-switch a{
  padding:7px 13px;font-size:.8rem;font-weight:600;color:var(--muted);
  min-width:44px;text-align:center;
}
.lang-switch a.on{background:var(--navy);color:#fff}
.lang-switch a:hover{text-decoration:none;background:var(--line-soft)}
.lang-switch a.on:hover{background:var(--navy)}

/* ---------- layout ---------- */
.wrap{max-width:1180px;margin:0 auto;padding:28px 20px 80px}
.hero{margin-bottom:26px}
.hero h1{font-size:clamp(1.5rem,3.4vw,2.1rem);color:var(--navy);font-weight:800}
.hero p{color:var(--muted);margin-top:8px;max-width:62ch}

.layout{display:grid;grid-template-columns:minmax(0,1fr) 340px;gap:24px;align-items:start}
@media (max-width:960px){ .layout{grid-template-columns:1fr} }

.card{
  background:var(--card);border:1px solid var(--line);border-radius:var(--radius);
  box-shadow:var(--shadow);padding:22px;
}
.card + .card{margin-top:18px}
.card-head{display:flex;align-items:flex-start;gap:12px;margin-bottom:18px}
.card-head h2{font-size:1.08rem;color:var(--navy);font-weight:700}
.card-head p{font-size:.86rem;color:var(--muted);margin:4px 0 0}
.card-num{
  flex:0 0 auto;width:28px;height:28px;border-radius:9px;background:var(--navy);color:#fff;
  display:grid;place-items:center;font-size:.82rem;font-weight:700;
}

/* ---------- mode selector ---------- */
.mode-grid{display:grid;grid-template-columns:1fr 1fr;gap:14px}
@media (max-width:640px){ .mode-grid{grid-template-columns:1fr} }
.mode-opt{
  position:relative;display:block;cursor:pointer;border:1.5px solid var(--line);
  border-radius:var(--radius);padding:18px 18px 18px 52px;background:#fff;transition:.16s;
  min-height:96px;
}
.mode-opt:hover{border-color:var(--teal);box-shadow:var(--shadow)}
.mode-opt input{position:absolute;opacity:0;pointer-events:none}
.mode-opt .dot{
  position:absolute;left:18px;top:20px;width:20px;height:20px;border-radius:50%;
  border:2px solid var(--line);background:#fff;transition:.16s;
}
.mode-opt .dot::after{
  content:"";position:absolute;inset:3px;border-radius:50%;background:var(--teal);
  transform:scale(0);transition:.16s;
}
.mode-opt strong{display:block;color:var(--navy);font-size:.98rem;margin-bottom:4px}
.mode-opt span.desc{display:block;font-size:.84rem;color:var(--muted);line-height:1.4}
.mode-opt:has(input:checked){border-color:var(--teal);background:#F4FBFA;box-shadow:0 0 0 3px rgba(18,165,148,.12)}
.mode-opt:has(input:checked) .dot{border-color:var(--teal)}
.mode-opt:has(input:checked) .dot::after{transform:scale(1)}

/* ---------- fields ---------- */
.field{margin-bottom:22px}
.field:last-child{margin-bottom:0}
.field-head{display:flex;align-items:baseline;justify-content:space-between;gap:12px;margin-bottom:8px}
.field label,.field .label{font-weight:600;font-size:.92rem;color:var(--navy)}
.field .unit{font-size:.78rem;color:var(--muted);font-weight:500}
.field .hint{font-size:.78rem;color:var(--muted);margin-top:6px}

.value-row{display:flex;align-items:center;gap:12px}
.value-box{
  display:flex;align-items:center;gap:6px;border:1.5px solid var(--line);border-radius:var(--radius-sm);
  padding:6px 10px;background:#fff;min-width:118px;
}
.value-box input{
  border:0;outline:0;font:inherit;font-weight:700;font-size:1.05rem;color:var(--navy);
  width:72px;text-align:right;background:transparent;
}
.value-box .u{font-size:.78rem;color:var(--muted);font-weight:600}

input[type=range]{
  -webkit-appearance:none;appearance:none;width:100%;height:34px;background:transparent;cursor:pointer;
}
input[type=range]::-webkit-slider-runnable-track{
  height:8px;border-radius:99px;
  background:linear-gradient(90deg,var(--teal) 0%,var(--teal) var(--p,50%),var(--line-soft) var(--p,50%),var(--line-soft) 100%);
}
input[type=range]::-moz-range-track{height:8px;border-radius:99px;background:var(--line-soft)}
input[type=range]::-moz-range-progress{height:8px;border-radius:99px;background:var(--teal)}
input[type=range]::-webkit-slider-thumb{
  -webkit-appearance:none;width:26px;height:26px;border-radius:50%;background:#fff;
  border:3px solid var(--teal);margin-top:-9px;box-shadow:0 2px 6px rgba(11,42,69,.18);
}
input[type=range]::-moz-range-thumb{
  width:22px;height:22px;border-radius:50%;background:#fff;border:3px solid var(--teal);
  box-shadow:0 2px 6px rgba(11,42,69,.18);
}
input[type=range]:focus-visible{outline:2px solid var(--accent);outline-offset:4px;border-radius:99px}
.scale{display:flex;justify-content:space-between;font-size:.72rem;color:var(--muted);margin-top:-4px}

/* segmented control */
.seg{display:inline-flex;border:1.5px solid var(--line);border-radius:999px;padding:3px;background:#fff;gap:2px}
.seg label{
  position:relative;cursor:pointer;padding:9px 16px;border-radius:999px;font-size:.86rem;
  font-weight:600;color:var(--muted);min-height:40px;display:flex;align-items:center;transition:.14s;
}
.seg input{position:absolute;opacity:0;pointer-events:none}
.seg label:has(input:checked){background:var(--navy);color:#fff}
.seg label:hover{color:var(--navy)}
.seg label:has(input:checked):hover{color:#fff}

/* switch */
.switch-row{display:flex;align-items:center;gap:14px;flex-wrap:wrap}
.switch{position:relative;display:inline-flex;align-items:center;gap:12px;cursor:pointer;min-height:44px}
.switch input{position:absolute;opacity:0;pointer-events:none}
.switch .track{
  width:56px;height:32px;border-radius:99px;background:var(--line);position:relative;transition:.18s;flex:0 0 auto;
}
.switch .track::after{
  content:"";position:absolute;top:3px;left:3px;width:26px;height:26px;border-radius:50%;
  background:#fff;box-shadow:0 1px 3px rgba(0,0,0,.2);transition:.18s;
}
.switch input:checked + .track{background:var(--teal)}
.switch input:checked + .track::after{transform:translateX(24px)}
.switch .switch-label{font-size:.9rem;font-weight:600;color:var(--navy)}

/* chips (genes / cytogenetics) */
.chips{display:flex;flex-wrap:wrap;gap:8px}
.chip{
  position:relative;display:inline-flex;align-items:center;gap:7px;cursor:pointer;
  border:1.5px solid var(--line);border-radius:999px;padding:9px 15px;background:#fff;
  font-size:.86rem;font-weight:600;color:var(--ink);min-height:42px;transition:.14s;user-select:none;
}
.chip:hover{border-color:var(--teal);background:#F7FCFB}
.chip input{position:absolute;opacity:0;pointer-events:none}
.chip .tick{
  width:16px;height:16px;border-radius:5px;border:1.5px solid var(--line);display:grid;place-items:center;
  font-size:11px;color:#fff;transition:.14s;flex:0 0 auto;
}
.chip:has(input:checked){background:var(--navy);border-color:var(--navy);color:#fff}
.chip:has(input:checked) .tick{background:var(--accent);border-color:var(--accent)}
.chip:has(input:checked) .tick::after{content:"✓"}
.chip.warn:has(input:checked){background:var(--bad);border-color:var(--bad)}
.chip.warn:has(input:checked) .tick{background:#fff;color:var(--bad)}
.chip.warn:has(input:checked) .tick::after{content:"✓"}

.subpanel{
  margin-top:14px;padding:14px 16px;border-radius:var(--radius-sm);
  background:#F7FAFB;border:1px dashed var(--line);
}
.subpanel .label{font-size:.82rem;font-weight:700;color:var(--navy);margin-bottom:8px;display:block}

/* derived badge */
.derived{
  display:flex;align-items:center;gap:12px;margin-top:16px;padding:14px 16px;border-radius:var(--radius-sm);
  background:#F4FBFA;border:1px solid #CBE9E4;
}
.derived .k{font-size:.78rem;color:var(--muted);font-weight:600;text-transform:uppercase;letter-spacing:.04em}
.derived .v{font-size:1rem;font-weight:800;color:var(--teal-700)}

/* ---------- stepper ---------- */
.stepper{display:flex;gap:6px;margin-bottom:20px;flex-wrap:wrap}
.stepper .s{
  flex:1;min-width:70px;height:5px;border-radius:99px;background:var(--line);
}
.stepper .s.on{background:var(--teal)}
.stepper .s.done{background:var(--navy)}

/* ---------- summary (sticky) ---------- */
.summary{position:sticky;top:84px}
@media (max-width:960px){ .summary{position:static} }
.summary .card{padding:20px}
.sum-title{font-size:.78rem;text-transform:uppercase;letter-spacing:.06em;color:var(--muted);font-weight:700;margin-bottom:14px}
.sum-score{font-size:2.6rem;font-weight:800;color:var(--navy);line-height:1;letter-spacing:-.03em;font-variant-numeric:tabular-nums}
.sum-score small{font-size:.9rem;font-weight:600;color:var(--muted);letter-spacing:0}
.sum-row{display:flex;justify-content:space-between;gap:10px;padding:9px 0;border-top:1px solid var(--line-soft);font-size:.86rem}
.sum-row .k{color:var(--muted)}
.sum-row .v{font-weight:700;color:var(--navy);font-variant-numeric:tabular-nums}

/* ---------- gauge ---------- */
.gauge{margin:18px 0 6px}
.gauge-track{
  position:relative;height:14px;border-radius:99px;overflow:hidden;display:flex;
  background:var(--line-soft);
}
.gauge-zone{height:100%}
.gauge-zone.bad{background:linear-gradient(90deg,#E8A9A4,#D46A62)}
.gauge-zone.mid{background:linear-gradient(90deg,#F0C98A,#E0A94E)}
.gauge-zone.ok{background:linear-gradient(90deg,#7FC79B,#2E9E63)}
.gauge-marker{
  position:absolute;top:-5px;width:4px;height:24px;border-radius:2px;background:var(--navy);
  box-shadow:0 0 0 3px #fff,0 2px 6px rgba(11,42,69,.3);transform:translateX(-50%);transition:left .35s cubic-bezier(.4,0,.2,1);
}
.gauge-labels{display:flex;justify-content:space-between;font-size:.7rem;color:var(--muted);margin-top:8px}

/* ---------- badges ---------- */
.badge{
  display:inline-flex;align-items:center;gap:6px;padding:5px 11px;border-radius:999px;
  font-size:.76rem;font-weight:700;letter-spacing:.01em;
}
.badge.ok{background:var(--ok-bg);color:var(--ok)}
.badge.mid{background:var(--warn-bg);color:var(--warn)}
.badge.bad{background:var(--bad-bg);color:var(--bad)}
.badge.neutral{background:var(--line-soft);color:var(--navy)}

/* ---------- result ---------- */
.result-hero{
  border-radius:var(--radius);padding:26px;color:#fff;
  background:linear-gradient(135deg,var(--navy) 0%,var(--navy-700) 55%,var(--teal-700) 100%);
  box-shadow:var(--shadow-lg);
}
.result-hero .k{font-size:.78rem;text-transform:uppercase;letter-spacing:.08em;opacity:.75;font-weight:700}
.result-hero .big{font-size:clamp(2.6rem,7vw,3.6rem);font-weight:800;line-height:1;margin:8px 0 4px;font-variant-numeric:tabular-nums}
.result-hero .verdict{font-size:1.02rem;font-weight:700;margin-top:10px}
.result-hero .verdict-d{font-size:.88rem;opacity:.85;margin-top:6px;max-width:60ch;line-height:1.45}
.result-hero .gauge-track{background:rgba(255,255,255,.18)}
.result-hero .gauge-marker{background:#fff;box-shadow:0 0 0 3px rgba(11,42,69,.5)}
.result-hero .gauge-labels{color:rgba(255,255,255,.7)}

.kpis{display:grid;grid-template-columns:repeat(auto-fit,minmax(150px,1fr));gap:12px;margin-top:18px}
.kpi{background:#fff;border:1px solid var(--line);border-radius:var(--radius-sm);padding:14px 16px}
.kpi .k{font-size:.74rem;text-transform:uppercase;letter-spacing:.05em;color:var(--muted);font-weight:700}
.kpi .v{font-size:1.35rem;font-weight:800;color:var(--navy);margin-top:4px;font-variant-numeric:tabular-nums}
.kpi .s{font-size:.76rem;color:var(--muted)}

/* contribution bars */
.bars{display:flex;flex-direction:column;gap:7px;margin-top:6px}
.bar-row{display:grid;grid-template-columns:120px 1fr 62px;gap:10px;align-items:center;font-size:.82rem}
.bar-row .n{color:var(--muted);font-weight:600;text-align:right;white-space:nowrap;overflow:hidden;text-overflow:ellipsis}
.bar-track{position:relative;height:16px;background:var(--line-soft);border-radius:5px;overflow:hidden}
.bar-fill{position:absolute;top:0;bottom:0;border-radius:5px}
.bar-fill.pos{background:linear-gradient(90deg,#E08A82,#C0504A);left:50%}
.bar-fill.neg{background:linear-gradient(90deg,#4FA97A,#2E8B5C);right:50%}
.bar-zero{position:absolute;left:50%;top:-2px;bottom:-2px;width:1px;background:var(--line)}
.bar-row .v{font-variant-numeric:tabular-nums;font-weight:700;color:var(--navy);text-align:right}

/* reference cohort */
.refbars{display:flex;gap:26px;align-items:flex-end;height:150px;padding:10px 6px 0}
.refbar{flex:1;display:flex;flex-direction:column;align-items:center;justify-content:flex-end;height:100%;gap:6px}
.refbar .col{width:100%;max-width:74px;border-radius:8px 8px 0 0;background:linear-gradient(180deg,var(--teal),var(--teal-700));position:relative;transition:height .5s}
.refbar .col span{position:absolute;top:-22px;left:0;right:0;text-align:center;font-size:.8rem;font-weight:800;color:var(--navy)}
.refbar .lbl{font-size:.76rem;color:var(--muted);font-weight:600;text-align:center}

/* alerts */
.alert{display:flex;gap:12px;padding:14px 16px;border-radius:var(--radius-sm);font-size:.86rem;line-height:1.45}
.alert.warn{background:var(--warn-bg);border:1px solid #F0D9AE;color:#6B4200}
.alert.bad{background:var(--bad-bg);border:1px solid #F0C4C0;color:#7A1A15}
.alert.info{background:#EEF6F8;border:1px solid #CFE4E9;color:#0B4A52}
.alert strong{display:block;margin-bottom:3px}

/* buttons */
.btn{
  display:inline-flex;align-items:center;justify-content:center;gap:9px;
  padding:13px 22px;border-radius:12px;border:1.5px solid transparent;
  font:inherit;font-weight:700;font-size:.94rem;cursor:pointer;min-height:48px;
  transition:.15s;text-decoration:none;
}
.btn:hover{text-decoration:none}
.btn-primary{background:var(--navy);color:#fff;box-shadow:0 6px 18px rgba(11,42,69,.18)}
.btn-primary:hover{background:var(--navy-700);transform:translateY(-1px)}
.btn-accent{background:var(--teal);color:#fff;box-shadow:0 6px 18px rgba(14,124,134,.22)}
.btn-accent:hover{background:var(--teal-700);transform:translateY(-1px)}
.btn-ghost{background:#fff;border-color:var(--line);color:var(--navy)}
.btn-ghost:hover{border-color:var(--teal);background:#F7FCFB}
.btn-row{display:flex;gap:12px;flex-wrap:wrap;margin-top:22px}
.btn-row .spacer{flex:1}

/* footer */
.site-footer{
  border-top:1px solid var(--line);background:#fff;margin-top:40px;
}
.footer-inner{
  max-width:1180px;margin:0 auto;padding:22px 20px;display:flex;gap:16px;
  align-items:center;justify-content:space-between;flex-wrap:wrap;font-size:.8rem;color:var(--muted);
}
.footer-brand{display:flex;align-items:center;gap:10px;font-weight:600;color:var(--navy)}
.footer-brand .wf{color:var(--teal-700);font-weight:800}

/* method page */
.prose{max-width:74ch}
.prose h2{font-size:1.15rem;color:var(--navy);margin:26px 0 10px}
.prose h3{font-size:.98rem;color:var(--navy);margin:18px 0 8px}
.prose ul{padding-left:20px;margin:0 0 12px}
.prose li{margin-bottom:6px}
.formula{
  background:var(--navy);color:#fff;border-radius:var(--radius-sm);padding:18px 20px;
  font-family:ui-monospace,SFMono-Regular,Menlo,Consolas,monospace;font-size:.92rem;
  overflow-x:auto;margin:14px 0;
}
table.tbl{width:100%;border-collapse:collapse;font-size:.86rem;margin:12px 0}
table.tbl th,table.tbl td{padding:9px 10px;border-bottom:1px solid var(--line-soft);text-align:left}
table.tbl th{font-size:.74rem;text-transform:uppercase;letter-spacing:.05em;color:var(--muted)}
table.tbl td.num{text-align:right;font-variant-numeric:tabular-nums}

/* print */
@media print{
  .site-header,.site-footer,.btn-row,.summary,.stepper,.no-print{display:none !important}
  body{background:#fff}
  .card{box-shadow:none;border-color:#ccc;break-inside:avoid}
  .result-hero{background:#0B2A45 !important;-webkit-print-color-adjust:exact;print-color-adjust:exact}
  .wrap{padding:0}
}

/* ---------- small screens ---------- */
@media (max-width:520px){
  .brand-sub{display:none}
  .header-inner{padding:10px 14px}
  .wrap{padding:20px 14px 60px}
  .card{padding:18px 16px}
  .hero h1{font-size:1.45rem}
  .result-hero{padding:20px}
  .kpis{grid-template-columns:1fr 1fr}
}